~is2.tmp is a temporary file used by the IP*Works software. This software is used by many large companies to develop their websites and intranets. It is not a malicious program, nor is ~is2.tmp a malicious file.
That being said, it is unlikely that the ~is2.tmp file needs to remain on a computer for long. Temporary files can often clutter up the Windows system registry, making the computer work more slowly.
There are a number of registry errors that can cause a computer to slow down. Some programs do not uninstall properly, but instead leave process files that run in the registry and basically spin their wheels with nowhere to go. These files may also become damaged by viruses (anti-virus programs seldom heal registry errors) or simply become out of date.
If you don’t want to take your computer to a PC technician or try and fix them yourself (which can be dangerous, as one wrong deleted entry can make your whole system malfunction), your best bet is to find a good registry cleaning software. You can get a free registry scan from ZookaWare PC Cleaner at http://regzooka.com.